BECLOMETHASONE DIPROPIONATE

PRODUCT IDENTIFICATION

CAS NO. 4419-39-0 (Base)
5534-09-8 (D
ipropionate)

BECLOMETHASONE DIPROPIONATE

EINECS NO. 224-585-9, 226-886-0
FORMULA C28H37ClO7
MOL WT. 521.05

H.S. CODE

 

TOXICITY

 

SYNONYMS Aldecin; Beclacin; BP2;
9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione- 17,21-dipropionate; Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl- 17,21-bis (1-oxopropoxy)-, (11beta,16beta)-; Becloval; Benconase;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White crystalline powder
MELTING POINT 210 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Slightly soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION  & APPLICATIONS

Beclomethasone, a synthetic glucocorticoid, is used in the treatment of bronchial asthma, perennial and seasonal rhinitis. It is used to shrink nasal polyps following after surgical removal. The dipropionate salt of beclomethasone is a white to creamy white powder; slightly soluble in water; soluble in chloroform, acetone and in alcohol; melting point 210 C; administered by inhalation . The chemical designation is 9-chloro-11beta, 17,21- trihydroxy-16beta-methylpregna-1,4-diene-3,20-doine, 17,21-dipropionate.

SALES SPECIFICATION

APPEARANCE

White to off-white crystalline powder

IDENTIFICATION

Complies

ASSAY

96.0 - 103.0%

OPTICAL ROTATION

+88° ~ +94°

RELATED SUBSTANCE

0.5% max (Beclomethasone 17 monpropionate)
0.5% max (Beclomethasone 21 monpropionate)
1.0% max (Total impurity)

SOLVENT RESIDUE

0.1% max

RESIDUE ON IGNITION

0.1% max

LOSS ON DRYING

0.5% max

TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 60-61-36-42/43, Safety Phrases: 53-22-36/37/39-45

GENERAL DESCRIPTION OF CORTICOSTEROID

Corticosteroid is a synthetic or naturally occurring 21-carbon steroid structure substances with four fused rings and vary functional branches attached to the ring system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid refers to these three groups that contain a hydrogenated cyclopentano perhydro phenanthrene ring system. In restricted context for medical usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal cortex in response to physiological carbohydrate metabolism. According to their predominant biologic activity, they are divided into two major groups: glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to regulate carbohydrate, lipid, and protein metabolism and inhibit the release of ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and the microcirculation, participate in the maintenance of arterial blood pressure, increase gastric secretion, alter connective tissue response to injury, impede cartilage production, inhibit inflammatory, allergic, and immunologic responses, invoke shrinkage of lymphatic tissue, reduce the number of circulating lymphocytes, and affect the functions of the central nervous system. In humans, the most important ones are cortisol, cortisone, and corticosterone. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Aldosterone plays a role also in promoting tissue repair. Spironolactone is the aldosterone antagonist called potassium-sparing diuretic used in the treatment of hypertension. Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses.
  • Glucocorticoid Receptor Agonists
    • Dexamethasone
    • Triamcinolone
    • Hydrocortisone
    • Prednisone
  • Glucocorticoid Receptor Antagonists
    • Mifepristone
    • Onapristone
  • Mineralocorticoid Receptor Agonists
    • Aldosterone
  • Mineralocorticoid Receptor Antagonists
    • Spironolactone
    • Eplerenone